Effect of Stem Cell Therapy on Bone Mineral Density

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BACKGROUND:

Preclinical studies of a healing purpose of stem cell formed therapy in animal models of osteoporosis have mostly yielded unsuitable results. We achieved a meta-analysis to yield an overview of a now accessible evidence.

METHODS:

Pubmed, Embase and Cochrane Library databases were evenly searched for applicable tranquil studies. A random-effect indication was used for pooled research of a outcome of stem cell formed therapy on bone vegetable firmness (BMD). Stratified analyses were achieved to try a outcome of investigate characteristics on a outcomes.

RESULTS:

Pooled formula from 12 preclinical studies (110 animals in stem cell diagnosis groups, and 106 animals in control groups) indicated thatstem cell formed diagnosis was compared with significantly softened BMD (standardized meant disproportion [SMD] = 1.29, 95% Confidence Interval [CI]: 0.84-1.74, P 0.001) with assuage heterogeneity (Cochrane’s Q test: P = 0.02, I2 = 45%) among a basic studies. Implantation of bone marrow cells, bone marrow mesenchymal branch cells, adipose-derived stem cells, and tellurian umbilical cord blood-derived CD34+ cells, were all compared with softened BMD as compared to that in a controls (P 0.05 for all); a usually difference being a use of embryonic stem cell transplantation (P 0.05). Egger’s exam rescued intensity announcement disposition (P = 0.055); however, ‘trim and fill’ research yielded identical formula after statistically incorporating a suppositious studies in a research (SMD = 1.24, 95% CI: 0.32-2.16, P 0.001).

CONCLUSIONS:

Stem cell transplantation might urge BMD in animal models of osteoporosis. Our meta-analysis indicates a intensity healing purpose of stem cell formed therapy for osteoporosis, and serves to enlarge a motive for clinical studies.

Source: PubMed