Researchers during a National Institutes of Health have detected a pivotal step in a routine that HIV uses to inject a genetic element into cells. Working with cultures of cells and tissues, a researchers prevented a advance routine by chemically restraint this step, preventing HIV genetic element from entering cells. The commentary could lead to a contingent growth of new drugs to forestall HIV infection.
The study, appearing in Cell Host Microbe, was led by Leonid V. Chernomordik, Ph.D., during NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
To taint a cell, a protein on a aspect of HIV binds to molecules on a cell’s surface. This contracting routine triggers a method of events that ends with HIV’s outdoor aspect fusing with a cell’s membrane. The virus’ genetic element afterwards passes into a cell. The researchers detected that a contracting routine activates a protein, called TMEM 16F, that transfers another proton inside a dungeon membrane, phosphatidylserine, to a membrane’s outdoor surface. They trust molecules in a viral aspect connect with a unprotected phosphatidylserine on a dungeon aspect to raise a virus’ alloy to a cell.
The researchers found that restraint a send of phosphatidylserine to a dungeon aspect — or attaching another proton to phosphatidylserine so it can’t connect with HIV — prevents a pathogen from infecting a cell. Theoretically, building drugs that could retard any of these stairs could yield a basement for treatments to forestall HIV from infecting cells, though most some-more investigate is needed.
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