A hormone deputy therapy might strengthen memory for some women, according to a new USC-led study.
The commentary by USC researchers are a latest to prove that hormone deputy therapy might have some benefits, deepening systematic discussions about a pros and cons of a menopausal treatment.
“Our investigate suggests that estrogen diagnosis after menopause protects a memory that is indispensable for short-term cognitive tasks from a effects of stress,” pronounced Alexandra Ycaza Herrera, a study’s lead author and a researcher during a USC Leonard Davis School of Gerontology.
Earlier studies have forked to intensity health risks of a treatment. A multiple therapy that uses both estrogen and progesterone has been related to a aloft risk of breast cancer, heart disease, stroke and blood clots.
The investigate was published in The Journal of Clinical Endocrinology and Metabolism.
Stress hinders recall
The researchers found that women holding estrogen-only therapy had reduce levels of a highlight hormone cortisol and achieved improved on tests of “working memory” following bearing to highlight compared to women holding a placebo.
Working memory allows a mind to keep information immediately accessible for processing, such as when a shopper uses a mental grocery list to collect adult equipment or when a tyro keeps specific numbers in mind as a clergyman reads a word problem aloud in math class. Studies have documented that highlight can deteriorate operative memory.
To magnitude a outcome of estrogen therapy on operative memory underneath stress, Ycaza Herrera recruited 42 women with an normal age of 66 from a USC Early contra Late Intervention Trial with Estradiol led by Howard Hodis, a highbrow during a Keck School of Medicine of USC and a co-author of a study.
Half of a postmenopausal women had been on estradiol, a form of estrogen therapy, for approximately 5 years, while a others had perceived a placebo.
Each member visited USC twice. To satisfy a highlight response during one visit, researchers asked participants to plunge their palm in ice H2O for about 3 minutes. For a control condition conducted during a other visit, a participants submerged their palm in comfortable water.
Before and after any visit, a researchers collected spit to magnitude a women’s levels of cortisol, estrogen, and progesterone. The researchers also ran a exam of operative memory called a “sentence camber task,” in that a women were any given a array and afterwards asked either any judgment done sense. They also were asked to remember a final word of any one.
Not right for each woman
All women achieved equally good on a judgment camber charge after a comfortable H2O condition. But after a ice bath, women holding a remedy gifted a spike in cortisol levels. They also demonstrated a diminution in operative memory function.
By contrast, women receiving estrogen therapy had a smaller boost in cortisol and showed no diminution in operative memory function.
“Hormone deputy therapy might not be right for each woman, though women need to be means to have a review with their doctors,” Ycaza Herrera said.
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