Intraarticular Injection of Allogenic Mesenchymal Stem Cells has a Protective Role for a Osteoarthritis

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Researchers primarily due a transformation of apoptotic chondrocytes in a extraneous cartilage by injecting mesenchymal branch cells (MSCs) intraarticularly. This outcome was termed as bio-resurfacing. Little justification ancillary a diagnosis of osteoarthritis (OA) by a smoothness of a MSC cessation exists. The aim of this examine was to examine a effects of injecting allogenic MSCs intraarticularly in a rodent OA indication and to weigh a change of immobility on a effects of this treatment.


We determined a rodent knee OA indication after 4 and 6 weeks and well-bred primary bone pith MSCs. A MSC cessation was injected into a articular space once per week for 3 weeks. A branch of knee joints was immobilized for 3 days after any injection, while a remaining joints were nonimmobilized. We used toluidine blue staining, Mankin scores, and TdT-mediated dUTP-biotin scrape finish labeling dirty to weigh a healing outcome of a injections. Comparisons between a therapy side and a control side of a knee corner were done regulating interconnected t-test, and comparisons between a immobilized and nonimmobilized subgroups were done regulating a unpaired t-test. A P value 0.05 was deliberate significant.


The 3 inquisitive approaches suggested reduction lapse on a therapy sides of a knee joints than a control sides in both a 4- and 6-week groups (P 0.05), regardless of immobilization. No poignant differences were celebrated between a immobilized and nonimmobilized subgroups (P 0.05).


Therapy involving a intraarticular injection of allogenic MSCs promoted cartilage correct in a rodent arthritis model, and 3-day immobility after injection had small outcome on this therapy.

Source: PubMed