Progression from unipolar basin to schizophrenia

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New investigate quantifies risk and risk factors for march from a diagnosis of unipolar basin to a diagnosis of schizophrenia in a Danish Central Psychiatric Research Register

Depressive symptoms are prevalent initial signs of illness among people who eventually rise schizophrenia, and are mostly a precipitating cause heading people in a prodromal proviso of schizophrenia to find psychiatric treatment. Without believe of a patient’s destiny illness course, it is formidable for clinicians to heed these people from patients who benefaction with depressive symptoms though will not rise schizophrenia.  Our aims in this investigate were to 1) quantify and impersonate a risk of march to schizophrenia among people with a diagnosis of unipolar basin and 2) brand groups of unipolar basin patients during towering risk of progression.

Using information from Danish Civil and Psychiatric registers, we identified a conspirator of 71,932 people who perceived their initial diagnosis of unipolar basin (ICD-10 codes F32, F33) in a psychiatric sanatorium trickery in Denmark between 1995 and 2013. We followed these people for a limit of 18.5 years to calculate a accumulative occurrence of schizophrenia (ICD-10 F20). We used cox regressions to brand characteristics compared with increasing jeopardy of progression.

The accumulative occurrence of schizophrenia over 18.5 years was 5.5% in women and 8.4% in men. Patient characteristics compared with risk for march enclosed younger age; masculine sex; larger severity, quadriplegic or puncture room diagnosis and crazy symptoms during index basin diagnosis; past or stream ethanol and unlawful piece use disorders, anorexia, celebrity disorders, or a commotion with crazy features; hearth outward Denmark; and parental story of schizophrenia or neurotic, stress-related, or somatoform disorders. Risk for receiving a schizophrenia diagnosis was top in a initial year following a index basin diagnosis and decreased usually over a subsequent 10 years. After 10 years, a risk of march was low, though remained consistent via a residue of a follow-up period. Groups of basin patients with opposite combinations of risk factors had increasingly towering risks for progression, with 10-year accumulative incidences trimming from 9% to 62%.

The essay “Progression from unipolar basin to schizophrenia” was published in Acta Psychiatrica Scandinavica, 2017 Jan;135(1):42-50.

Source: Aarhus University

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