Therapeutic focus of MSCs in osteoarthritis

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Osteoarthritis (OA) is a degenerative illness characterized by cartilage plunge and subchondral bone alterations. This illness represents a tellurian open health problem whose superiority is fast flourishing with a augmenting aging of a population. With a find of mesenchymal branch cells (MSC) as probable healing agents, their intensity for repair cartilage repairs in OA is underneath investigation.


Characterization of MSCs and their organic properties are mentioned with an discernment into their trophic duty and secretory profile. We benefaction a special concentration on a forms of extracellular vesicles (EVs) that are constructed by MSCs and their purpose in a paracrine activity of MSCs. We afterwards plead a healing approaches that have been evaluated in pre-clinical models of OA and a formula entrance out from a clinical trials in patients with OA.


MSC-based therapy seems a earnest proceed for a diagnosis of patients with OA. Further investigate is still indispensable to denote their efficiency in clinical trials regulating controlled, impending studies. However, a presentation of MSC-derived EVs as probable healing agents could be an choice to cell-based therapy.

Source: PubMed